Low concentration of PDGF-AB shows synergism with IFN-¦Á in induction of IFN-¦Â and -¦Ã in MRC5 fibroblasts

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• 作者：G. ?antak ; M. ?antak ; D. For?i?
• 关键词：PDGF-AB ; Interferon-¦Á ; Interferon-¦Â ; Interferon-¦Ã ; Synergy
• 刊名：Cytokine
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：64
• 期：2
• 页码：494-496
• 全文大小：506 K

文摘

Platelet-derived growth factor (PDGF) is a potent mediator of fibroblast proliferation and chemotaxis. Also it has been reported as a strong suppressor of interferon (IFN) expression. IFN-¦Á has opposite effect on fibroblast function and IFN induction. Here is our early report on the effect of low concentration of PDGF-AB alone or in combination with IFN-¦Á on IFN mRNA production in MRC5 fibroblasts. MRC5 cells incubated with IFN-¦Á or PDGF-AB, alone or in combination, produced significant induction of IFN-¦Á, -¦Â and -¦Ã mRNA in comparison with untreated cells. The induction was dose-dependent, with higher effect in cells treated with lower concentrations of PDGF-AB. Also, low concentration of PDGF-AB showed synergism with IFN-¦Á in IFN-¦Â and -¦Ã induction. Results presented here open new possibilities in multi-cytokine therapy and expand previous results on PDGF activity.