Reticulocyte production index as a predictor of clinically significant anemia in chronic hepatitis C patients receiving pegylated interferon combination therapy

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• 作者：Sheng-Lei Yan^a ; Cheng-Shyong Chang^b ; Chien-Hua Chen^a ; ^c ; ^{yslendo@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yung-Hsiang Yeh^a ; ^c ; Chien-Yu Tsai^b
• 关键词：Anemia ; Hepatitis C ; Pegylated interferon ; Reticulocyte production index
• 刊名：Advances in Digestive Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：3
• 期：1
• 页码：18-23
• 全文大小：719 K

文摘

This work was conducted to study the relationship of reticulocyte production index to clinically significant anemia in chronic hepatitis C patients receiving pegylated interferon combination therapy.

Methods

A total of 69 chronic hepatitis C patients receiving pegylated interferon combination therapy were included. Clinically significant anemia was defined as a hemoglobin level of < 10 g/dL. Reticulocyte count values were determined at the baseline and during treatment (4 weeks, 12 weeks, and 24 weeks). Reticulocyte production indices were calculated according to formulae. Clinical variables were analyzed using univariate analysis. Variables that were found to be significant on univariate analysis were included in multivariate analysis. A p value < 0.05 was regarded as statistically significant.

Results

Clinically significant anemia was observed in 30 patients (43.5%), and 39 patients (56.5%) never developed clinically significant anemia during the whole treatment course. On multivariate analysis, age > 60 years [odds ratio (OR), 2.94; 95% confidence interval (CI), 1.09–7.93], pretreatment hemoglobin level < 14 g/dL (OR, 5.76; 95% CI, 2.01–16.48), and reticulocyte production index < 0.9% (OR, 5.50; 95% CI, 1.78–16.97) at Week 4 were significantly associated with clinically significant anemia.

Conclusion

Besides old age and low pretreatment hemoglobin level, our study showed that a reticulocyte production index < 0.9% at Week 4 was a significant factor associated with clinically significant anemia during pegylated interferon combination treatment.