Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis
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- 作者：Stephanie D. Boomkampa ; Hoe-Sup Byunb ; Satvir Ubhia ; Hui-Rong Jianga ; Susan Pynea ; Robert Bittmanb ; Nigel J. Pynea ; n.j.pyne@strath.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：DAMPs ; danger associated molecular patterns ; DMEM ; dulbeccos modified eagles medium ; EAE ; experimental autoimmune encephalomyelitis ; ERK ; extracellular signal regulated kinase ; LPS ; lipopolysaccharide ; NLRP3 ; NOD like receptor familypyrin domain containing 3 ; IFNγ ; interferon gamma ; IL-1β ; interleukin-1beta ; PAF ; platelet activating factor ; PAMPs ; pathogen-associated molecular patterns ; PP2A ; protein phosphatase 2A ; PP1 ; protein phosphatase 1 ; SK ; sphingosine kinase ; S1P ; sphingosine 1-phosphate
- 刊名：Chemistry and Physics of Lipids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：194
- 期：Complete
- 页码：2-11
- 全文大小：1597 K
文摘
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The glycerol lipid 77-6 stimulated IL-1β release from macrophages.
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This involves activation of the inflammasome and caspase 1.
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The glycerol lipid 56-5 promotes EAE disease progression.
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This is independent of the inflammasome and might involve modulation of PAF signalling.
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Glycerol lipids might be a starting point for development of anti-inflammatory drugs.