Crocin attenuate Tumor Necrosis Factor-alpha (TNF-α) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta
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- 作者：Saeed Samarghandiana ; samarghandians@mums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mohsen Azimi-Nezhada ; b ; Tahereh Farkhondehc
- 关键词：DM ; diabetes mellitus ; ROS ; reactive oxygen species ; AGE ; advanced glycation end product ; TNF-α ; tumor necrosis factor-alpha ; IL-6 ; interleukin-6 ; IL-1β ; interleukin-1beta ; ICAM-1 ; inter cellular adhesion molecule-1 ; DN ; diabetes nephropathy ; HDL ; high density lipoprotein ; LDL ; low density lipoprotein ; i.p. ; intraperitoneal ; STZ ; streptozotocin ; MDA ; malondialdehyde ; GSH ; glutathione ; CAT ; catalase ; SOD ; superoxide dismutases ; NO ; nitric oxide ; TCA ; trichloracetic acid ; TBARS ; thiobarbituric aci
- 刊名：Cytokine
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：20-28
- 全文大小：1647 K
文摘
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Diabetes-induced hyperglycemia was suppressed by crocin in dose-dependent manner.
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Diabetes-increased lipid profile was suppressed by crocin in dose-dependent manner.
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Diabetes mellitus-induced the reduction in MAD level was suppressed by crocin.
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Diabetes-induced the reduction in GSH, SOD and CAT levels were ameliorated by crocin.
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Diabetes-induced TNF-α and IL-6 gene expressions were inhibited by crocin.