Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus
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- 作者：Belé ; n Gó ; mez-Gimé ; nez ; Marta Llansola ; mllansola@cipf.es ; Vicente Herná ; ndez-Rabaza ; Andrea Cabrera-Pastor ; Michele Malaguarnera ; Ana Agusti ; Vicente Felipo
- 关键词：Pesticides ; Spatial learning ; Development ; Gender ; Interleukins ; Hippocampus
- 刊名：Food and Chemical Toxicology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：99
- 期：Complete
- 页码：135-148
- 全文大小：3882 K
- 卷排序：99
文摘
Different pesticides impair spatial learning in male, but not in female rats. Cypermethrin induces opposite effects on spatial learning in two different tests. Pesticides alter the hippocampal content of glutamate and GABA receptor subunits. Pesticides are able to alter cytokine levels in the hippocampus. Hippocampal levels of interleukin-1beta correlate with spatial learning and memory.