Comparison of serum concentrations of C-reactive protein, TNF-α, and interleukin 6 between elderly Korean women with normal and impaired glucose tolerance
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- 作者：Choi ; K.M. ; Lee ; J. ; Lee ; K.W. ; Seo ; J.A. ; Oh ; J.H. ; Kim ; S.G. ; Kim ; N.H. ; Choi ; D.S. ; Baik ; S.H.
- 关键词：HOMA ; homeostasis model assessment ; IR ; insulin resistance ; CRP ; C-reactive protein ; TNF-α ; tumor necrosis factor α ; IL-6 ; interleukin 6 ; Type 2 diabetes ; Impaired glucose tolerance ; Interleukin 6 ; Tumor necrosis factor α ; C-reactive protei
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2004
- 出版时间：May, 2004
- 年：2004
- 卷：64
- 期：2
- 页码：99-106
- 全文大小：148 K
文摘
This study was performed to compare concentrations of pro-inflammatory cytokines, such as interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) as well as acute-phase protein, such as C-reactive protein (CRP) between subjects with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT). The purpose of this study was to verify whether the pro-inflammatory cytokine-induced acute-phase response is a pathogenic mechanism in type 2 diabetes in elderly Korean women. A total of 1737 elderly subjects aged over 60 years participated in a population based study in Seoul, Korea (SWS Study 1999). Amongst them, a total of 232 non-smoking and non-diabetic female subjects aged 60–89 years was randomly selected and compared with each other. Higher serum high-sensitivity CRP (hs-CRP) concentrations were shown in subjects with IGT than those with normal glucose tolerance (median 1.2 versus 0.9, P<0.05). Moreover, a relationship between serum hs-CRP concentrations and many components of the metabolic syndrome were detected. Serum pro-inflammatory cytokine IL-6 or TNF-α concentrations, however, were neither increased in subjects with IGT nor closely correlated with the components of the metabolic syndrome. In multiple regression analysis with stepwise selection method using hs-CRP as a dependent variable, it was found that white blood cell (WBC) counts, body mass index (BMI), fasting insulin, post-load 2h glucose, hematocrit and LDL cholesterol were significant independent variables. Our study confirms that increased acute-phase reaction is associated with impaired glucose tolerance and the metabolic syndrome in elderly Korean women. However, the hypothesis that pro-inflammatory cytokine-induced systemic inflammation is an early metabolic defect prior to onset of type 2 diabetes, is not supported in our study of elderly Korean women.