157-P: INTERLEUKINES GENES POLIMORPHISM IN PATIENTS WITH BLADDER CANCER

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• 作者：Alberto J. Leon¹ ; Victoriano J. Leon² ; Javier Garcia³ ; Manuel Urrutia³
• 刊名：Human Immunology
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：73
• 期：supp_S
• 页码：146
• 全文大小：32 K

文摘

Aim

12 Transitional Cell Carcinomas (4 G1, 8 G2), and a control group (24) have been studied.

Methods

The DNA was obtained from blood samples extracted with the kit DNA Direct II (Dynal), for the genomic studies were employed Cytokine genotiping Kit(Pel-freez).

Results

Control Group: IL-1alpha/- 889 (52.5 CC/40 CT/7.5 TT), IL-1beta/-511 (40 CC/45 CT/15 TT), IL-1beta/396 (60 CC/35CT/5 TT), IL-1RA/mspa 11100 (5 CC/47.5 CT/47,5 TT), IL1R/psti 1970 (50 CC/40 CT/10 TT), IL-2/- 330 (15 GG/45 GT/40 TT), IL-2/166 (50 GG/40 GT/10 TT), IL-4/- 1098 (10 GG/27.5 GT/62,5 TT), IL-4/- 590 (72.5 CC/25 CT/2,5 TT), IL-4/- 33 (75 CC/20 CT/5 TT), IL-4R alpha/1902 (60 AA/35 AG/5 GG), IL-6/- 174 (20 CC/40CG/40 GG), IL-6/565 (12.5 AA/52,5 AG/35 GG), IL-10/- 592 (5 AA/45 AC/50 CC), IL-10/- 819 (50 CC/40 CT/10 TT), IL-10/- 1082 (25 AA/50AG/25 GG), IL-12/- 1188 (62.5 AA/32.5 AC/5CC), IFN gamma/utr 5644 (32.5 AA/42,5 AT/25 TT), TNF alpha/- 238 (0 AA/2O AG/80 GG), TNF alpha/- 308 (10 AA/25 AG/65 GG), TGF beta1/codon 10 (25 CC/50 CT/25 TT), TGF beta1/codon 25 (0 CC/15 CG/85 GG)

TCC Group

IL-1alpha/- 889 (57.5 CC/40 CT/2.5 TT), IL-1beta/-511 (40 CC/50 CT/10 TT), IL-1beta/3962 (50 CC/32.5CT/7.5 TT), IL-1RA/mspa 11100 (0CC/50 CT/50 TT), IL1R/psti 1970 (45 CC/52.5 CT/7.5 TT), IL-2/- 330 (15 GG/50 GT/35 TT), IL-2/166 (55 GG/35 GT/10 TT), IL-4/- 1098 (10 GG/22 GT/70 TT), IL-4/- 590 (75CC/25 CT/0 TT), IL-4/- 33 (75 CC/20 CT/5 TT), IL-4R alpha/1902 (75 AA/15 AG/10 GG), IL-6/- 174 (15CC/45CG/40 GG), IL-6/nt 565 (10 AA/50 AG/40 GG), IL-10/- 592 (5 AA/45 AC/50 CC), IL-10/- 819 (55 CC/35 CT/10 TT) IL-10/- 1082 (20 AA/50AG/30 GG), IL-12/- 1188 (65 AA/35 AC/0 CC), IFN gamma/utr 5644 (35 AA/40AT/25 TT), TNF alpha/- 238 (0 AA/2O AG/80 GG), TNF alpha/- 308 (5 AA/30 AG/65 GG), TGF beta1/codon 10 (20 CC/50 CT/30 TT), TGFbeta1/codon 25 (0 CC/15CG85 GG).

Conclusions

The Chi-square test does not show differences P < 0. 01 inter control and Control group.