Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event
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- 作者：Fré ; dé ; ric Boala ; 1 ; 2 ; Lorna R. Hodgsona ; 2 ; Sam E. Reeda ; 2 ; Sophie E. Yarwooda ; Victoria J. Justa ; David J. Stephensa ; Mary W. McCaffreyb ; Jeremy M. Tavaré ; a ; j.tavare@bris.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insulin ; Rip11 ; Rab ; Recycling ; Endocytosis
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：28
- 期：1
- 页码：74-82
- 全文大小：1029 K
文摘
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Rip11 translocates constitutively to the plasma membrane on Rab11-vesicles.
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Inhibition of Rip11 internalisation by insulin requires dynamin.
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Rip11 accumulation at the plasma membrane is PI3-K dependent but Akt-independent.