Robustness testing in the determination of seven drugs in animal muscle by liquid chromatography-tandem mass spectrometry
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- 作者：M.L. Ocaa ; L. Rubioa ; M.C. Ortiza ; mcortiz@ubu.es" class="auth_mail" title="E-mail the corresponding author ; L.A. Sarabiab ; I. Garcí ; ac
- 关键词：ICH ; International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use ; IUPAC ; International Union of Pure and Applied Chemistry ; LC/MS&ndash ; MS ; Liquid chromatography coupled to tandem mass spectrometry ; XYL ; Xylazine ; AZA ; Azaperone ; PROP ; Propionylpromazine ; CHLOR ; Chlorpromazine ; HALO ; Haloperidol ; AZOL ; Azaperol ; CAR ; Carazolol ; SPE ; Solid-phase extraction ; MRL ; Maximum residue limit ; IS ; Internal standard ; APCI ; Atmospheric pressure chemi
- 刊名：Chemometrics and Intelligent Laboratory Systems
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：172-180
- 全文大小：771 K
文摘
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Robustness study of the sample preparation step to determine sedatives by LC/MS–MS.
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Seven factors evaluated through a Youden design according to the European legislation.
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Results interpreted from quite useful methodologies when the residual error is unknown.
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Lenth's and Bayes' approaches for robustness testing when performing saturated designs.