Might Interspecific Interactions between Pathogens Drive Host Evolution? The Case of Plasmodium Species and Duffy-Negativity in Human Populations

详细信息    查看全文

• 作者：Benjamin Roche¹ ; ² ; ^{benjamin.roche@ird.fr} ; Virginie Rougeron² ; Lluis Quintana-Murci³ ; Franç ; ois Renaud² ; Jessica Lee Abbate¹ ; ² ; Franck Prugnolle²
• 刊名：Trends in Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：1
• 页码：21-29
• 全文大小：1957 K
• 卷排序：33

文摘

Malarial infections have long been recognized as a driver of human evolution, as demonstrated by the influence of Plasmodium falciparum on sickle-cell anemia persistence. Duffy-negativity is another blood disorder thought to have been selected because it confers nearly complete resistance against Plasmodium vivax infection. Recent evidence suggests that the benefits of being Duffy-negative cannot be expected to play a strong selective pressure on humans, whereas its costs cannot be considered as negligible. Here, we suggest that the cross-talk between P. falciparum and P. vivax in coinfected children could represent the most parsimonious explanation of the frequency of Duffy-negativity. We discuss how this new hypothesis could be tested and call for a reconsideration of the evolution of the Duffy-negative group.