Exposure to metal oxide nanoparticles in physiological fluid induced synergistic biological effects in a keratinocyte model

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• 作者：Deidre S. Cathe¹ ; Jasmine N. Whitaker¹ ; Emily K. Breitner ; Kristen K. Comfort ; ^{kcomfort1@udayton.edu}
• 关键词：Interstitial fluid ; Nanotoxicity ; Copper oxide ; Titanium dioxide ; Oxidative stress
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：268
• 期：Complete
• 页码：1-7
• 全文大小：1444 K
• 卷排序：268

文摘

Synergistic toxicity occurred during joint CuO NP and interstitial fluid exposure. This observed toxicity correlated with increased NP agglomeration and deposition. Physiological fluids provide a means to characterize NPs in relevant environments.