Understanding flow patterns and inflammatory status in intracranial aneurysms: Towards a personalized medicine

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• 作者：Jé ; rô ; me Berge^a ; ^{jerome.berge@chu-bordeaux.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Blanco^b ; Caroline Rooryck^c ; Romain Boursier^d ; Gaultier Marnat^a ; Florent Gariel^a ; Thomas Wavasseur^a ; Hubert Desal^d ; Vincent Dousset^a
• 关键词：Interventional neuroradiology ; Intracranial aneurysm ; Personalized medicine ; Endovascular treatment ; Inflammation
• 刊名：Journal of Neuroradiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：43
• 期：2
• 页码：141-147
• 全文大小：289 K

文摘

Unruptured intracranial aneurysms are frequently and incidentally discovered with noninvasive imaging and the decision for preventive treatment is supported by epidemiologic and statistics data, lacking personalized argumentation about individual aneurysm behavior and inflammatory status of its wall. After a review of hemodynamic forces leading to aneurysm genesis and interaction with inflammation onset within aneurysmal wall, we will successively detail routine imaging methods for the aneurysmal wall and their respective contribution. Then, we will draw up the inventory of different experimental imaging and in vitro methods for future investigation of the aneurysmal wall. We emphasize the need for cooperation with various specialties: histopathology, genetics, and immunology in order to understand the natural history of the aneurysmal sac leading most often to stability but elsewhere to aneurysmal growth, thrombosis or rupture. A description of a research protocol devoted to aneurysmal wall inflammation and recently accepted in our university is introduced.