Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice

详细信息    查看全文

• 作者：Dina Montufar-Solis¹ ; Alexander Williams ; Nadarajah Vigneswaran ; John R. Klein ; ^{john.r.klein@uth.tmc.edu}
• 关键词：Costimulation ; Inflammation ; Intestine ; Proinflammatory cytokine ; Roquin
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：590-595
• 全文大小：1710 K
• 卷排序：483

文摘

IELs cannot be isolate using standard techniques from sanroque mice. There is increased expression of Ly6C on LPLs in sanroque mice. Costimulation via Ly6C increases production of IL-17A, IFN-γ, and TNFα from sanroque LPLs. There is increased 4-1BB expression on LPLs from sanroque mice. TNFα expression by sanroque LPLs is associated with a subset of 4-1BB + KLRG1-cells.