Prospective experimental animal study in the setting of research laboratory. Male New Zealand White rabbits weighting 2.7 kg ¡À 0.1 kg, were anesthetized and the AWE was determined by infusion of lactated Ringer's solution into the peritoneal cavity whilst the IAP was measured. A meta-analysis of peer-reviewed studies was conducted to define human AWE.
The described AWE was lower in the rabbit than in humans. The function comparing human and rabbit was: loge human IAP = (0.58 loge rabbit IAP + 1.6).
The AWE can vary amongst species. This study determined the relationship to allow the comparison of rabbit and human IAP. The proposed mathematical function is important for the advancement of interpretation and understanding of animal research into IAH and ACS. We recommend developing model-specific functions comparing individual animal models?IAP and that of humans.