Protective Role of Cross-Reactive CD8 T Cells Against Dengue Virus Infection

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• 作者：Annie Elong Ngono^a ; Hui-Wen Chen^b ; William W Tang^a ; Yunichel Joo^a ; Kevin King^a ; Daniela Weiskopf^c ; John Sidney^c ; Alessandro Sette^c ; Sujan Shresta^a ; ^{sujan@lji.org}
• 关键词：Ab ; antibody ; ADE ; antibody dependent enhancement ; DENV ; dengue virus ; DHF ; dengue hemorrhagic fever ; DSS ; dengue shock syndrome ; HLA ; human leukocyte antigen ; ICS ; intracellular cytokine staining ; IFN ; interferon ; NS ; non-structural ; PBMC ; Peripheral Blood Mononuclear Cells
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：284-293
• 全文大小：1055 K
• 卷排序：13

文摘

Serotype-cross-reactive CD8 T cells elicit a polyfunctional immune response similar to the response elicited by serotype-specific CD8 T cells. Serotype cross-reactive CD8 T cells play a role in protection against DENV infection in a HLA-B*0702 Transgenic IFN-α/βR−/− mouse model.There are four major subtypes (serotypes) of the mosquito-borne Dengue virus. Infection with a first serotype is generally asymptomatic, but secondary infection with a different serotype is capable of causing severe disease. T cells previously exposed to a first serotype and which produce an immune response to a second serotype are said to be cross-reactive. Using a mouse model engineered with human T cell features, we characterized the cross-reactive T cell response to live dengue virus serotypes and viral protein fragments. Our results suggested cross-reactive T cells contribute to control of and protection against infection by a second dengue serotype, rather than leading to more severe disease.