Isolated Cerebellar Spindle Cell Pseudotumor Caused by Mycobacterium Avium-Intracellulare Complex in a Patient without AIDS

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• 作者：Ming-Sheng Lim¹ ; ^{mingsheng.lim@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Niamh Bermingham² ; Cathal O'Broin³ ; Ayman Khalil¹ ; Catherine Keohane² ; Chris Lim¹
• 关键词：Cerebellum ; Intracranial ; Mycobacterium avium complex ; T-lymphocytopenia idiopathic CD4-positive
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：90
• 期：Complete
• 页码：703.e1-703.e3
• 全文大小：920 K

文摘

Spindle cell pseudotumors are formed by histiocytes in response to infection by Mycobacterium avium-intracellulare complex (MAC) and are rare in patients without AIDS.

Case Description

A 66-year-old man presented with neck pain, ataxia, and a history of sarcoidosis. A cerebellar lesion was identified on magnetic resonance imaging and surgically excised. Histopathology revealed this to be a spindle cell pseudotumor and MAC was isolated by bacterial culture of cerebrospinal fluid. Hematology revealed cluster of differentiation 4 lymphocytopenia but human immunodeficiency virus serology was negative. The patient was commenced on antimicrobial treatment that included a macrolide and remained well at 1 year follow-up.

Conclusions

This rare presentation of isolated intracranial MAC was treated with surgical excision and antimicrobials with a good outcome.