Clipping or Extracting: Two Ways to Membrane Protein Degradation

详细信息    查看全文

• 作者：Dö ; nem Avci¹ ; ^# ; Marius K. Lemberg¹ ; ^{m.lemberg@zmbh.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：organellar protein homeostasis ; intramembrane proteolysis/protease ; AAA-ATPase p97/VCP/Cdc48 ; endoplasmic reticulum-associated protein degradation
• 刊名：Trends in Cell Biology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：25
• 期：10
• 页码：611-622
• 全文大小：2240 K

文摘

Protein degradation is a fundamentally important process that allows cells to recognize and remove damaged protein species and to regulate protein abundance according to functional need. A fundamental challenge is to understand how membrane proteins are recognized and removed from cellular organelles. While most of our understanding of this mechanism comes from studies on p97/Cdc48-mediated protein dislocation along the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, recent studies have revealed intramembrane proteolysis to be an additional mechanism that can extract transmembrane segments. Here, we review these two principles in membrane protein degradation and discuss how intramembrane proteolysis, which introduces an irreversible step in protein dislocation, is used to drive regulated protein turnover.