SnapShot: Cartography of Intramembrane Proteolysis

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• 作者：Sini&scaron ; a Urban
• 刊名：Cell
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：167
• 期：7
• 页码：1898-1898.e1
• 全文大小：6731 K
• 卷排序：167

文摘

Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.