Recent Advances in Pancreatic Cancer Surgery of Relevance to the Practicing Pathologist

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• 作者：Lennart B. van Rijssen ; MD^a ; Steffi J.E. Rombouts ; MD^b ; Marieke S. Walma ; MD^b ; Jantien A. Vogel ; MD^a ; Johanna A. Tol ; MD ; PhD^a ; Isaac Q. Molenaar ; MD ; PhD^b ; Casper H.J. van Eijck ; MD ; PhD^c ; Joanne Verheij ; MD ; PhD^d ; Marc J. van de Vijver ; MD ; PhD^d ; Olivier R.C. Busch ; MD ; PhD^a ; Marc G.H. Besselink ; MD ; MSc ; PhD^a ; ^{m.g.besselink@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author} ; For the Dutch Pancreatic Cancer Group
• 关键词：Whipple ; Pancreatoduodenectomy ; Pancreas ; Surgery ; Pathology ; Lymph node ; Neoadjuvant ; Radiofrequency ablation
• 刊名：Surgical Pathology Clinics
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：4
• 页码：539-545
• 全文大小：1100 K

文摘

Recent advances in pancreatic surgery have the potential to improve outcomes for patients with pancreatic cancer. We address 3 new, trending topics in pancreatic surgery that are of relevance to the pathologist. First, increasing awareness of the prognostic impact of intraoperatively detected extraregional and regional lymph node metastases and the international consensus definition on lymph node sampling and reporting. Second, neoadjuvant chemotherapy, which is capable of changing 10% to 20% of initially unresectable, to resectable disease. Third, in patients who remain unresectable following neoadjuvant chemotherapy, local ablative therapies may change indications for treatment and improve outcomes.