Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats
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- 作者：Li-hua Yanga ; 1 ; Guang-min Xub ; 1 ; Yu Wangb ; yuwangdoctor@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CFA ; complete freund&rsquo ; s adjuvant ; CXCL1 ; chemokine (C-X-C motif) ligand 1 ; GAPDH ; glyceraldehydes 3-phosphate dehydrogenase ; GSK-3β ; glycogen synthase kinase-3β ; i.t. ; intrathecally ; i.v. ; intravenously ; NMDA ; N-methyl-d-aspartate ; NS ; normal saline ; PWL ; paw withdrawal thermal latency ; PWT ; Paw withdrawal mechanical threshold ; RIH ; remifentanil-induced hypernociception ; SD ; standard deviation
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 July 2016
- 年：2016
- 卷：626
- 期：Complete
- 页码：135-141
- 全文大小：1493 K
文摘
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Remifentanil exposure could enhance postoperative mechanical and thermal hypernociception.
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Increase of spinal CXCL1 and CXCR2 expression in remifentanil induced hypernociception.
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Increase of spinal NR2B-containing NMDA receptor expression and activity in remifentanil-induced hypernociception.
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Intrathecal delivery of SB225002 could ameliorate remifentanil induced postoperative hypernociception.
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Inhibitory effects of SB225002 on spinal NR2B-containing NMDA receptor expression and activity in remifentanil-induced hypernociception.