Remifentanil anesthesia could elicit postoperative mechanical and thermal hyperalgesia.
Up-regulation of WNT3a, FZ8 and β-catenin in spinal dorsal horn in remifentanil-induced postoperative hyperalgesia.
Changes of spinal fractalkine and CX3CR1 expression in remifentanil-induced postoperative hyperalgesia.
Intrathecal delivery of Fz-8/Fc and anti-CX3CR1 could attenuate remifentanil-induced postoperative hyperalgesia.
WNT inhibition could reduce spinal fractalkine and CX3CR1 expression in remifentanil-induced postoperative hyperalgesia.