Anti-Müllerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination

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• 作者：Francesca Moro^a ; ^{morofrancy@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Anna Tropea^a ; Elisa Scarinci^a ; Emanuele Leoncini^b ; Stefania Boccia^b ; Alex Federico^a ; Ornella Alesiani^a ; Antonio Lanzone^a ; ¹ ; Rosanna Apa^a ; ¹
• 关键词：Anti-Mü ; llerian hormone ; Antral follicle count ; Intrauterine insemination ; Ovulation induction ; Prediction
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：133
• 期：1
• 页码：64-68
• 全文大小：522 K

文摘

To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination.

Methods

A retrospective study included women with unexplained infertility aged 41 years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression.

Results

Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 2.3 ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 2.3 ng/mL (odds ratio 5.84, 95% confidence interval 2.38–14.31; P < 0.001). No associations were recorded for AFCs.

Conclusion

AMH should be used to predict the pregnancy outcome of intrauterine insemination.