Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure
In an ischemia-reperfusion canine model, iVNS markedly reduced infarct size and preserved LV function one month later. The bradycardic effect plays an important role in the beneficial effect of iVNS. Intravenous VNS may be a novel therapeutic strategy and contribute to improve the long-term survival in patients with AMI.