KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK
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- 作者：Cameron G. Goertzena ; Magdalena Dragana ; Eva Turleyb ; c ; d ; g ; Andy V. Babwaha ; e ; f ; h ; Moshmi Bhattacharyaa ; b ; f ; moshmi.bhattacharya@schulich.uwo.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kisspeptin ; KISS1R ; β-Arrestin ; Triple negative breast cancer ; Invasion ; Invadopodia
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：28
- 期：3
- 页码：165-176
- 全文大小：2901 K
文摘
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The G protein coupled receptor, KISS1R stimulates invadopodia formation and is localized to invadopodia
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KISS1R signaling stimulates MT1-MMP activation, that regulates ECM degradation at the leading edge of invasive cancer cells
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KISS1R stimulates invadopodia formation via β-arrestin-2/ERK dependent mechanism, independent of Src.