MAITs, MR1 and vitamin B metabolites

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• 作者：Richard W Birkinshaw ; Lars Kjer-Nielsen ; Sidonia BG Eckle ; James McCluskey ; Jamie Rossjohn
• 刊名：Current Opinion in Immunology
• 出版年：February, 2014
• 年：2014
• 卷：26
• 期：Complete
• 页码：7-13
• 全文大小：1631 K

文摘

伪尾T-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of 伪尾T-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cells, can recognise metabolites of vitamin B, when presented by the MHC-related protein, MR1. The semi-invariant MAIT T-cell antigen receptor (TCR) recognises riboflavin and folic acid metabolites bound by MR1 in a conserved docking mode, and thus acts like a pattern recognition receptor. Here we review and discuss the recent observations concerning antigen presentation by MR1, the advent of MR1-Ag tetramers that specifically stain MAIT cells, recognition by the MAIT TCR, and our emerging understanding of MAIT cells in disease.