Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancer

详细信息    查看全文

• 作者：Daohai Zhang ; Des R. Richardson
• 关键词：Endoplasmic reticulum protein 29 (ERp29) ; ER stress ; Mesenchymal– ; epithelial transition ; Tumor suppressor ; Protein folding ; Chaperone
• 刊名：The International Journal of Biochemistry and Cell Biology
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：43
• 期：1
• 页码：33-36
• 全文大小：253 K

文摘

The endoplasmic reticulum protein 29 (ERp29) is a molecule that facilitates processing and transport of proteins in the early secretory pathway. Structural and functional analyses have suggested a biological role as a putative chaperone in the endoplasmic reticulum. The N-terminal domain of ERp29 resembles the thioredoxin domain of protein disulfide isomerase, but lacks its redox-active function due to the absence of an active motif consisting of double cysteines. In the context of carcinogenesis, the role of ERp29 in cancer progression has not been fully elucidated. However, recent studies indicate that high expression of ERp29 inversely correlates to tumor progression. In addition, over-expression of ERp29 significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal–epithelial transition in breast cancer cells. In this review, we summarize the biological properties of ERp29 and its novel function as a tumor suppressor.