NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice
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- 作者：Thomas V.A. Murraya ; Xuebin Donga ; Greta J. Sawyera ; Anna Caldwellb ; John Halketb ; Roy Sherwoodc ; Alberto Quagliad ; Tracy Dewc ; Narayana Anilkumara ; Simon Burra ; Rajesh K. Mistrya ; Daniel Martina ; Katrin Schrö ; dere ; Ralf P. Brandese ; Robin D. Hughesd ; Ajay M. Shaha ; Alison C. Brewera ; alison.brewer@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT ; alanine-transaminase ; AST ; aspartate-transaminase ; APAP ; acetaminophen (paracetamol) ; BHMT ; betaine-homocysteine methyltransferase ; BIAM ; N-(biotinoyl)-N'-(iodoacetyl)ethylenediamine ; CBS ; cysthathionine β-synthase ; CGL ; cystathionine γ-lyase ; DMG ; dimethylglycine ; GCL ; γ-glutamylcysteine ligase ; GSH ; Glutathione ; GS ; glutathione synthetase ; GSSG ; oxidised glutathione ; GWAS ; genome-wide association analysis ; Hcy ; Homocysteine ; MS ; methionine synthase ; NAC ; N-acetyl cysteine ; NADQI ; N-acetly
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：918-930
- 全文大小：2526 K
文摘
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Ablation of Nox4 results in lowered plasma homocysteine levels in mice.
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This results from increased folate-independent remethylation of homocysteine.
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As a consequence mice display reduced hepatic cysteine and glutathione.
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Reduced glutathione levels render the mice susceptible to hepatotoxic agents.
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Nox4 is a physiological regulator of partitioning of homocysteine metabolic flux.