Characterization of the S. cerevisiae inp51 mutant links phosphatidylinositol 4,5-bisphosphate levels with lipid content, membrane fluidity and cold growth
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- 作者：Isaac Có ; rcoles-Sá ; eza ; 1 ; Maria Luisa Herná ; ndezb ; Jose Manuel Martí ; nez-Rivasb ; Jose A. Prietoa ; Francisca Randez-Gila ; randez@iata.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Yeast ; Inositol phosphates ; Diphosphoinositol phosphates ; IP7 ; Pho85 ; Pah1
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1861
- 期：3
- 页码：213-226
- 全文大小：1791 K
文摘
- 5">
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5">Increased metabolism of PI(4,5)P2 increases reduces the activity of the Pho85 kinase.
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This effect is key in the cold tolerance phenotype of the inp51 mutant.
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5">Reduced Pho85 function by loss of Inp51 affected the activity of Pah1 phosphatase.
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Cells lacking Inp51 showed reduced lipid content and membrane fluidity.
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5">Additional Pho85-regulated targets appear to play a role in cold tolerance.