An Arterial Based Complexity (ABC) Scoring System to Assess the Morbidity Profile of Partial Nephrectomy

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• 作者：Massimiliano Spaliviero^a ; Bing Ying Poon^b ; Christoph A. Karlo^c ; Giuliano B. Guglielmetti^a ; Pier Luigi Di Paolo^c ; Renato Beluco Corradi^a ; Alexandre G. Martin-Malburet^a ; Felix Campos-Juanatey^d ; Eva Escudero-Fontano^e ; Daniel D. Sjoberg^b ; Paul Russo^a ; Jonathan A. Coleman^a ; Oguz Akin^c ; Karim A. Touijer^a ; ^{touijera@mskcc.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Kidney neoplasms ; Nephrometry ; Observer variation ; Outcome assessment ; Partial nephrectomy
• 刊名：European Urology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：69
• 期：1
• 页码：72-79
• 全文大小：1828 K

文摘

Tumor characteristics affect surgical complexity and outcomes of partial nephrectomy (PN).

Objective

To develop an Arterial Based Complexity (ABC) scoring system to predict morbidity of PN.

Design, setting, and participants

Four readers independently scored contrast-enhanced computed tomography images of 179 patients who underwent PN.

Intervention

Renal cortical masses were categorized by the order of vessels needed to be transected/dissected during PN. Scores of 1, 2, 3S, or 3H were assigned to tumors requiring transection of interlobular and arcuate arteries, interlobar arteries, segmental arteries, or in close proximity of the renal hilum, respectively during PN.

Outcome measurements and statistical analysis

Interobserver variability was assessed with kappa values and percentage of exact matches between each pairwise combination of readers. Linear regression was used to evaluate the association between reference scores and ischemia time, estimated blood loss, and estimated glomerular filtration rates at 6 wk and 6 mo after surgery adjusted for baseline estimated glomerular filtration rate. Fisher's exact test was used to test for differences in risk of urinary fistula formation by reference category assignment.

Results and limitations

Pairwise comparisons of readers’ score assignments were significantly correlated (all p < 0.0001); average kappa = 0.545 across all reader pairs. The average proportion of exact matches was 69%. Linear regression between the complexity score system and surgical outcomes showed significant associations between reference category assignments and ischemia time (p < 0.0001) and estimated blood loss (p = 0.049). Fisher's exact test showed a significant difference in risk of urinary fistula formation with higher reference category assignments (p = 0.028). Limitations include use of a single institutional cohort to evaluate our system.

Conclusions

The ABC scoring system for PN is intuitive, easy to use, and demonstrated good correlation with perioperative morbidity.

Patient summary

The ABC scoring system is a novel anatomy-reproducible tool developed to help patients and doctors understand the complexity of renal masses and predict the outcomes of kidney surgery.