Modeling ALS and FTD with iPSC-derived neurons

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• 作者：Sebum Lee^a ; Eric J. Huang^a ; ^b ; ^{eric.huang2@ucsf.edu}
• 关键词：Induced pluripotent stem cells (iPSCs) ; Amyotrophic lateral sclerosis (ALS) ; Frontotemporal dementia (FTD) ; Frontotemporal lobar degeneration (FTLD)
• 刊名：Brain Research
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：1656
• 期：Complete
• 页码：88-97
• 全文大小：731 K
• 卷排序：1656

文摘

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTD) are two ends of a disease spectrum. Comprehensive summary of studies that use iPSC-derived neurons to model ALS and FTD. Balanced discussions on the unique capabilities of iPSC-derived neurons that capture some key features of ALS and FTD. Highlight the potentials of iPSC-derived neurons in drug discovery and therapeutics. Identify critical caveats that require improvements before iPSC-derived neurons can become highly effective disease models.