Back and forth in time: Directing age in iPSC-derived lineages

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• 作者：Daniela Cornacchia ; Lorenz Studer ; ^{studerl@mskcc.org}
• 关键词：iPSC-disease modeling ; Neurodegenerative diseases ; Aging ; Rejuvenation ; Maturation ; Induced in vitro aging
• 刊名：Brain Research
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：1656
• 期：Complete
• 页码：14-26
• 全文大小：1432 K
• 卷排序：1656

文摘

Reprogramming to pluripotency rewinds biological clock of cell maturation and age. Immaturity and rejuvenation limit basic and clinical applications of iPSCtechnology Review of current and future methodologies for improving cell maturation. iPSC disease-modeling presents challenges for age-dependent diseases Of “induced in vitro aging” for modeling late-onset disorders using iPSC.