Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells

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• 作者：Jo茫o Agostinho Machado-Neto ; Paula de Melo Campos ; Patricia Favaro ; Mariana Lazarini ; Irene Lor ; -Metze ; Fern ; o Ferreira Costa ; Sara Teresinha Olalla Saad ; Fabiola Traina
• 关键词：Stathmin 1 ; OP18 ; Myelodysplastic syndromes ; Acute myeloid leukemia ; Acute lymphoid leukemia
• 刊名：Leukemia Research
• 出版年：February, 2014
• 年：2014
• 卷：38
• 期：2
• 页码：251-257
• 全文大小：1131 K

文摘

Stathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies.