The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomes
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- 作者：Richelle Mychasiuk ; rmmychas@ucalgary.ca" class="auth_mail" title="E-mail the corresponding author ; Harleen Hehar ; Sydeny Candy ; Irene Ma ; Michael J. Esser
- 关键词：Concussion ; Prefrontal cortex ; Hippocampus ; qRT-PCR ; Sprague Dawley rats
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：257
- 期：Complete
- 页码：168-178
- 全文大小：1381 K
文摘
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The lingering deficits of mTBI may arise from damage to neural networks & fibre tracts.
The directionality of injury impact and force alters the tracts and networks affected.
Rodents exposed to horizontal rotation/acceleration differed from the lateral group.
Differences were evident in behavioural testing and molecular biomarkers.
Rodents can be used to study functional deficits associated with white matter damage.