Host genetics of severe influenza: from mouse Mx1 to human IRF7
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- 作者：Michael J Ciancanelli1 ; mici751@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author ; Laurent Abel1 ; 2 ; 3 ; Shen-Ying Zhang1 ; 2 ; 3 ; Jean-Laurent Casanova1 ; 2 ; 3 ; 4 ; 5
- 刊名：Current Opinion in Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：109-120
- 全文大小：522 K
文摘
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Severe influenza can be caused by single-gene inborn errors of immunity in mice and humans.
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Mouse Mx1 was the first influenza susceptibility gene identified by forward genetics.
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Inherited IRF7 deficiency caused life-threatening influenza in an otherwise healthy child.
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Susceptibility genes are presumably influenza-specific as most patients are healthy before and after severe influenza.