Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review

详细信息    查看全文

• 作者：Le Zhang^a ; ^b ; Kunhua Wei^b ; Jianping Xu^a ; ^b ; Dawei Yang^a ; Chunhong Zhang^a ; Zhipeng Wang^d ; Minhui Li^a ; ^b ; ^c ; ^{prof_liminhui@yeah.net" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AMPK ; Adenosine 5&prime ; -Monophosphate-Activated Protein Kinase ; COX-1 ; Cyclooxygenase-1 ; COX-2 ; Cyclooxygenase-2 ; Ca2+-ATPase ; Calcium Pump ; CPAE ; Calf Pulmonary Arterial Endothelial ; CCl4 ; Carbon Tetrachloride ; DPPH ; 1 ; 1-Diphenyl-2-Picrylhydrazyl ; ETOH ; Ethanol ; EMSA ; Electrophoretic Mobility Shift Assay ; ELISA ; Enzyme-Linked Immunosorbent Assay ; ERα ; Estrogen Receptor Alpha ; ERβ ; Estrogen Receptor β ; GSH ; Glutathione ; GSH-px ; Glutathione Peroxidase ; hTERT ; Human Telomerase Reverse Transcripta
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：20 June 2016
• 年：2016
• 卷：186
• 期：Complete
• 页码：1-13
• 全文大小：897 K

文摘

Belamcanda chinensis (L.) DC is the sole species in the genus Belamcanda Adans. (Iridaceae), found mainly in Northeast Asia. Bombus chinensis has long been used in traditional Chinese medicine for its multiple therapeutic uses in the form of antipyretic agents, antidote, expectorant, antiphlogistic and analgesic.

Aim of the review

This manuscript comprehensively summarizes the various studies published in recent years on the botany, ethnopharmacology, phytochemistry, biological activity and toxicology of B. chinensis. We hope to provide a foundation for future studies on the mechanism of action and development of better therapeutic agents based on B. chinensis.

Material and methods

All information available on B. chinensis was collected using electronic search engines, such as PubMed, SciFinder Scholar, CNKI, TPL (www.theplantlist.org), Google Scholar and Web of Science.

Results

The analysis shown that ethno-medical uses of B. chinensis have been recorded in China, Japan and Korea since a long time. Based on a phytochemical investigation, this plant contains flavonoids, terpenoids, quinones, phenolic compounds, ketones, organic acids, etc. Crude extracts and pure compounds isolated from B. chinensis exhibited various biological effects.

Conclusions

In light of its long traditional use and the modern phytochemical and pharmacological studies summarized here, B. chinensis is known to be a promising medicinal plant with the isolated extracts and chemical components showing a wide range of biological activities. Thus, it is imperative that the necessary programs and value assessment of B. chinensis be established for further studies. It is also important that the synergistic or antagonistic effects of this traditional herbal medicine are investigated in depth to identify more bioactive components by bioactivity-guided isolation strategies, and to illustrate the mechanisms of action targeting on ethnomedical uses. Future clinical studies can also focus on the main therapeutic aspects, toxicity and adverse effects of B. chinensis.