Electrically responsive microreservoires for controllable delivery of dexamethasone in bone tissue engineering
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- 作者：Irina Alexandra Pauna ; b ; irina.paun@physics.pub.ro" class="auth_mail" title="E-mail the corresponding author ; irina_paun2003@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Marian Zamfirescub ; Catalin Romeo Luculescub ; catalin.luculescu@inflpr.ro" class="auth_mail" title="E-mail the corresponding author ; Adriana Maria Acasandreic ; Cosmin Catalin Mustaciosuc ; Mona Mihailescua ; Maria Dinescub ; dinescum@nipne.ro" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polymer ; Two photon polymerization ; MAPLE ; Osteoblasts ; Drug delivery
- 刊名：Applied Surface Science
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：392
- 期：Complete
- 页码：321-331
- 全文大小：3343 K
文摘
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Electrically-responsive microreservoires (ERRs) for controlled release of Dex.
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ERRs made of microtubes produced by two photon polymerization of IP-L780 photoresist.
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Microtubes loaded with PPy/Dex mixture and sealed with a thin PLGA layer.
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Kinetics of Dex release controlled by electrical stimulation of the ERRs.
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Controlled Dex release accelerates the cells osteogenic differentiation.