• 作者：Miguel Sag¨¹¨¦s ; Juan-Manuel Sancho ; David Serrano ; Pascual Balsalobre ; Jorge Gayoso ; Mireia Morgades ; Eulogio Conde ; Arturo Iriondo ; Rosario Varela ; Lourdes Escoda ; Blanca Xicoy ; Ildefonso Espigado ; Pascual Fern¨¢ndez-Abell¨¢n ; Jose-Luis D¨ªez ; Josep-Mar¨ªa Ribera
• 关键词：Virus de la inmunodeficiencia humana ; Movilizació ; n de progenitores hematopoyé ; ticos de sangre perifé ; rica ; Linfoma ; G-CSF ; Quimioterapia
• 刊名：Medicina Clnica
• 出版年：2012
• 出版时间：21 July, 2012
• 年：2012
• 卷：139
• 期：5
• 页码：192-196
• 全文大小：241 K

Background and objective

Several studies have demonstrated the feasibility of autologous stem cell transplantation (ASCT) in patients with lymphoma and human immunodeficiency virus (HIV) infection. HIV infection has been described as a risk factor for poor mobilization. The aim of this study was to compare the results of two mobilization strategies of peripheral blood stem cells (PBSC) in patients with lymphoma and HIV infection in seven Spanish hospitals.

Patients and methods

The following variables were collected: demographic, clinical and biological features, previous chemotherapies and outcomes, as well as mobilization's strategies (classified in two groups: 1) G-CSF, and 2) G-CSF + chemotherapy).

Results

Between January 2000 and May 2010, 42 patients with lymphoma and HIV infection were referred for ASCT. The rate of successful mobilization (collection >1.60 ¡Á 10⁶ CD34 cells/kg) with the first regimen was 67 % , with no differences between those patients mobilized with G-CSF or with G-CSF + chemotherapy (16 [72 % ] and 12 [60 % ], respectively; p = 0.382). The status of the lymphoma at the time of mobilization was the only factor for successful mobilization (20/22 patients [91 % ] in complete remission [CR] mobilized adequately versus 5/12 [58 % ] in partial remission [PR]; p = 0.038).

Conclusions

In patients with lymphoma and HIV infection, mobilization with G-CSF was as effective as mobilization with chemotherapy followed by G-CSF. The stage of disease prior to the mobilization was the main risk factor for the success of mobilization, with better results in patients mobilized in remission of the lymphoma.