The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs
详细信息 查看全文
- 作者：Amit Mandoli1 ; 7 ; Abhishek A. Singh1 ; 7 ; Koen H.M. Prange1 ; Esther Tijchon1 ; Marjolein Oerlemans1 ; Rene Dirks1 ; Menno Ter Huurne1 ; Albertus T.J. Wierenga2 ; 3 ; Eva M. Janssen-Megens1 ; Kim Berentsen1 ; Nilofar Sharifi1 ; Bowon Kim1 ; Filomena Matarese1 ; Luan N. Nguyen1 ; Nina C. Hubner1 ; Nagesha A. Rao1 ; Emile van den Akker4 ; Lucia Altucci5 ; 6 ; Edo Vellenga2 ; Hendrik G. Stunnenberg1 ; Joost H.A. Martens1 ; 5 ; 8 ; j.martens@ncmls.ru.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：AML1-ETO ; acute myeloid leukemia ; epigenome ; RUNX1 ; iPSC ; apoptosis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：17
- 期：8
- 页码：2087-2100
- 全文大小：4833 K
文摘
- •
Global analysis of AML1-ETO (AE) in two patient blasts
- •
The AML1-ETO complex consists of hematopoietic, chromatin, and splicing regulators
- •
ERG or RUNX1 knockdown upregulates AML1-ETO expression
- •
AML1-ETO overexpression in differentiated iPSCs induces apoptosis