- 作者：L. Assis&dagger ; ; a ; livinha_fisio@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; L.P. Milares&dagger ; ; a ; T. Almeida&dagger ; ; C. Tim&Dagger ; ; A. Magri&dagger ; ; K.R. Fernandes&dagger ; ; C. Medalha&dagger ; ; A.C. Muniz Renno&dagger ;
- 关键词：Low-level laser therapy ; Articular cartilage ; Knee osteoarthritis ; Rehabilitation
- 刊名：Osteoarthritis and Cartilage
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：24
- 期：1
- 页码：169-177
- 全文大小：1390 K
Material and methods
Fifty male Wistar rats were randomly divided into five groups: control group (CG); knee OA control group (OAC); OA plus exercise training group (OAT); OA plus LLLT group (OAL); OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill; 16 m/min; 50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint; 24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks.
Results
The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1β, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT.
Conclusion
These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.