Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage

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• 作者：Ahmed M. Salem^a ; Tarek F. Mohammaden^b ; Mohamed A.M. Ali^a ; ^{mohd_ali2@sci.asu.edu.eg" class="auth_mail" title="E-mail the corresponding author} ; Enas A. Mohamed^b ; Hesham F. Hassan^c
• 关键词：Ellagic acid ; Ferulic acid ; Gamma radiation ; Aluminium chloride ; Oxidative stress
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：1 September 2016
• 年：2016
• 卷：160
• 期：Complete
• 页码：2-11
• 全文大小：1160 K

文摘

Ionizing radiation interacts with biological systems through the generation of free radicals, which induce oxidative stress. Aluminium (Al) can negatively impact human health by direct interaction with antioxidant enzymes. Ellagic acid (EA) and Ferulic acid (FA) are plant polyphenolic compounds, have gained attention due to their multiple biological activities. To date, no studies investigating the antioxidant effect of EA/FA in a model involving both γ radiation and aluminium chloride (AlCl₃) have been reported. Herein, we investigated the protective effect of EA and FA against oxidative stress induced by γ radiation and AlCl₃ in rats.

Methods

Rats were divided into thirteen groups: a negative control group, 3 positive control groups (γ-irradiated, AlCl_3 − treated and γ-irradiated + AlCl_3 − treated) and 9 groups (3 γ-irradiated, 3 AlCl_3 − treated and 3 γ-irradiated + AlCl_3 − treated) treated with EA and/or FA. Liver function and lipid profile were assessed. Levels of lipid peroxidation, protein oxidation and endogenous antioxidants as well as the concentrations of copper, iron and zinc were estimated in liver tissue homogenate. Furthermore, liver tissue sections were histologically examined.

Results

Oral administration of EA and/or FA resulted in 1) amelioration of AlCl₃ and/or γ-radiation-induced hepatic function impairment, dyslipidemia and hepatic histological alterations; 2) reduction in liver MDA and PCC levels; 3) elevation of liver CAT, GPx and SOD activity as well as GSH level; 4) elevation in liver Cu concentrations which was accompanied by a reduction in Fe and Zn concentrations.

Conclusions

Oral administration of EA and/or FA may be useful for ameliorating γ radiation and/or AlCl₃-induced oxidative damage.