Effect of G-CSF on oral mucositis and traumatic ulcers produced in the tongue of rats undergoing radiotherapy: clinical and histologic evaluation

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• 作者：Juliana Jasper ; DDS^a ; ^{jujasper@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sé ; rgio Roithmann ; MD ; MSc^b ; Renata Stifelman Camilotti ; DDS^c ; Fernanda Gonç ; alves Salum ; DDS ; PhD^d ; Karen Cherubini ; DDS ; PhD^e ; Maria Antonia Zancanaro de Figueiredo ; DDS ; PhD^e
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：122
• 期：5
• 页码：587-596
• 全文大小：2356 K

文摘

To investigate the effect of granulocyte colony-stimulating factor (G-CSF) on oral mucositis (OM) and on the healing of traumatic ulcers produced in the tongue of rats undergoing radiotherapy (RT).

Study Design

Twenty-seven Wistar rats were assigned to four groups: (1) RT + traumatic ulcer + filgrastim (G-CSF analog; n = 7); (2) RT + traumatic ulcer + saline (n = 7); (3) no RT + traumatic ulcer + filgrastim (n = 7); and (4) no RT + traumatic ulcer (n = 6). The radiation dose was 30 Gy, and medication was filgrastim (10 μg/kg) for 7 days.

Results

Clinically, groups differed in the presence (Fisher's exact test: P = .008) and size of traumatic ulcers after irradiation (Kruskal-Wallis test: P = .032) and in the severity of OM (Fisher's exact test: P = .005 between the irradiated groups). Histologically, there was an increased inflammatory response in the nonirradiated groups (Fisher's exact test: P = .001).

Conclusions

Filgrastim reduced manifestations and the severity of trauma-induced ulcers and radiation-induced OM. Significant differences were not observed histologically between the study drug and respective control groups.