Modulation of gamma-irradiation and carbon tetrachloride induced oxidative stress in the brain of female rats by flaxseed oil
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- 作者：Amel F.M. Ismaila ; afmismail@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Asmaa A.M. Salemb ; Mamdouh M.T. Eassawyb
- 关键词：Flaxseed Oil ; carbon tetrachloride ; γ-irradiation ; xanthine oxidase and inducible nitric oxide synthase gene expression ; pro-inflammatory cytokines ; and trace elements
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：91-99
- 全文大小：1099 K
文摘
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The protective role of flaxseed oil on CCl4 and γ-radiation induced brain injury was studied in rats
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CCl4 and radiation induced brain injury proved by elevation in MDA, XO, iNOS, TNF-α, and IL-6 levels.
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CCl4 caused depletion of antioxidant enzymes: SOD, CAT, GPx activities and GSH level.
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Flaxseed oil exerts significant amelioration of the studied parameters.
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Flaxseed oil has a neuroprotective effect against CCl4-induced brain injury in irradiated rats.