Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat
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- 作者：Amel F.M. Ismaila ; afmismail@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Asmaa A.M. Salemb ; Mamdouh M.T. Eassawyb
- 关键词：Grape seed oil ; Carbon tetrachloride ; γ-Irradiation ; Nuclear factor κB ; Inducible nitric oxide synthase ; Cytochrome P450 2E1 (CYP2E1) ; Silent information regulator protein 1 gene expression
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：1-10
- 全文大小：1133 K
文摘
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The protective role of grape seed oil on CCl4 induced liver injury in γ-irradiated rat was studied.
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Grape seed oil (GSO) exerts significant amelioration of antioxidant and antiinflammatory status.
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GSO ameliorated CYP2E1, iNOS, NF-κB, TNF-α, and IL-6 levels.
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GSO exhibits activation of SIRT1 gene expression.
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GSO had a hepatoprotective effect against CCl4-induced acute liver injury in γ-irradiated rats.