Exploration and comparison of in vitro eye irritation tests with the ISO standard in vivo rabbit test for the evaluation of the ocular irritancy of contact lenses
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- 作者：Jun-Won Yuna ; 1 ; Quan Hailianb ; 1 ; Yirang Nab ; Byeong-Cheol Kanga ; Jung-Hee Yoona ; Eun-Young Choa ; Miri Leec ; Da-eun Kimc ; SeungJin Baec ; Seung Hyeok Seokb ; lamseok@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Kyung-Min Limc ; kmlim@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Eye irritation ; Animal alternative ; Reconstructed human corneal epithelium ; RhCE model ; BCOP ; Contact lens ; ISO10993-10 ; Medical device
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：37
- 期：Complete
- 页码：79-87
- 全文大小：1228 K
文摘
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Here, we did in vitro eye irritation tests using RhCE and BCOP for contact lens extracts.
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Positive controls and 4 representative contact lens were tested in vitro and in vivo.
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In vitro tests produced comparable results to in vivo and combination of BCOP and RhCE yielded the most reliable results.