MicroRNA-181b suppresses TAG via target IRS2 and regulating multiple genes in the Hippo pathway
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- 作者：Zhi Chen ; HuaiPing Shi ; Shuang Sun ; HuiFen Xu ; DuoYao Cao ; Jun Luo ; luojun@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-181b ; Fat metabolism ; Hippo pathway ; IRS2
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：348
- 期：1
- 页码：66-74
- 全文大小：2358 K
文摘
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After screening miRNAs in periods of peak-lactation and late-lactation, we have concluded that miR-181b shows a higher expression.
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We established the regulating relation between miR-181b and its target gene IRS2, and conducted the rescue experiment to prove that miR-181b exercises its function indeed via IRS2.
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We made a further research and discussion about the function of miR-181b and Wnt signaling pathway in the GMEC.