Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway
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- 作者：Marina Ruiz de Galarreta ; Amaia Navarro ; Eduardo Ansorena ; Antonia Garcí ; a Garzó ; n ; Teresa Mò ; dol ; Marí ; a J. Ló ; pez-Zabalza ; Juan J. Martí ; nez-Irujo ; Marí ; a J. Iraburu ; miraburu@unav.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSC ; hepatic stellate cells ; ER ; endoplasmic reticulum ; BFA ; Brefeldin A ; IRE1α ; inositol-requiring enzyme 1 alpha ; ATF6α ; activating transcription factor 6α ; PERK ; PKR-like ER kinase ; PBA ; phenylbutyric acid ; ERK ; extracellular-regulated kinase ; JNK ; Jun-N-terminal MAPK ; MAPK ; mitogen-activated protein kinase ; p38 MAPK ; p38 mitogen-activated protein kinase
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1863
- 期：8
- 页码：2115-2123
- 全文大小：1111 K
文摘
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UPR induced by Brefeldin A in hepatic stellate cells causes an increase in collagen I mRNA levels.
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IRE1α and p38 MAPK mediate Smad3 activation and collagen I enhancement in hepatic stellate cells.
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Activation of p38 MAPK in response to Brefeldin A is IRE1α-dependent.
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The increase in collagen I levels caused by UPR occurs through IRE1α-p38 MAPK-Smad3 activation.