• 作者：Celia Cifuentes ; Jos¨¦ A. Mira ; Julio Vargas ; Karin Neukam ; Carmen Escassi ; Silvia Garc¨ªa-Rey ; Isabel Gilabert ; Marian Gonz¨¢lez-Monclova ; Samuel Bernal ; Juan A. Pineda
• 关键词：Virus de la inmunodeficiencia humana (VIH) ; Virus de la hepatitis C (VHC) ; Virus de la hepatitis B (VHB) ; Virus de la hepatitis A (VHA)
• 刊名：Enfermedades Infecciosas y Microbiolog¨ªa Cl¨ªnica
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：30
• 期：8
• 页码：452-457
• 全文大小：258 K

Objectives

To determine: (a) The prevalence of active infection by the hepatitis C virus (HCV) and hepatitis B virus (HBV) in HIV-infected patients, as well as previous exposure to hepatitis A virus (HAV), HBV and HCV. (b) The proportion of patients who have been vaccinated against HAV and/or HBV. (c) The HCV genotype distribution and the percentage of patients who have started treatment against HCV infection.

Methods

All HIV-infected patients who attended the Infectious Diseases Unit of a tertiary care hospital in Southern Spain between September 2008 and February 2009 were included in a prospective cross-sectional study.

Results

A total of 520 patients were included. Three hundred and fifty-eight (69 % ) patients had positive HCV antibody, while 71 % of them showed detectable HCV-RNA. The HCV genotype distribution was: 153 (62 % ) genotype 1, 49 (20 % ) genotype 3, and 45 (18 % ) genotype 4. One hundred and thirteen (36.5 % ) subjects had received treatment against HCV. The prevalence of active HBV infection was 4.4 % , while the exposure to HBV was 54.8 % . Four hundred and thirty-seven (84 % ) patients had positive markers of infection of HAV. Of the patients eligible to be vaccinated, 25.6 % and 22.3 % patients were vaccinated against HAV and HBV, respectively.

Conclusions

The current prevalence of active HCV infection remains high in our area. There were no changes in the HCV genotype distribution. The number of patients with indication for HBV and HAV vaccination and receive these vaccines is low.