Endogenous sex hormones affect the mutagen-induced chromosome damage by altering a caffeine-sensitive checkpoint

详细信息    查看全文

• 作者：Cocchi ; Leonardo ; Scarcelli ; Vittoria ; Puliti ; Aldamaria ; Barale ; Roberto ; Sbrana ; Isabella
• 关键词：Endogenous hormones ; Menstrual cycle ; Mitomycin C ; Caffeine ; Sister chromatid exchanges (SCE)
• 刊名：Mutation Research Regular Papers
• 出版年：2005
• 出版时间：March 1, 2005
• 年：2005
• 卷：570
• 期：2
• 页码：281-288
• 全文大小：171 K

文摘

In the present study we analysed the effect of endogenous sex hormones on the SCE frequencies induced in vitro by mitomycin C (MMC), a bifunctional alkylating agent producing high chromosome damage and mitotic arrest. The analysis has been performed on lymphocytes obtained at three different phases of menstrual cycle, from women with regular cycle and hormones dosage. At all phases we further analysed the effect of a post-treatment with caffeine, an agent that it is known to overrride the DNA damage checkpoints.