Modulating factors of individual sensitivity to diepoxybutane: sister chromatid exchanges induced in vitro in human lymphocytes

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• 作者：Landi ; Stefano ; Frenzilli ; Giada ; Sbrana ; Isabella ; Barale ; Roberto
• 关键词：Diepoxybutane ; Genotoxicity ; Sister chromatid exchange ; Peripheral lymphocyte ; Human ; Life style
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：1996
• 出版时间：October 25, 1996
• 年：1996
• 卷：357
• 期：1-2
• 页码：75-82
• 全文大小：654 K

文摘

Spontaneous and diepoxybutane (DEB)-induced sister chromatid exchanges (SCEs) were examined in cultured peripheral lymphocytes (PBL) from 122 healthy donors. SCE-inducing activity under defined experimental conditions and individual sensitivity to genotoxic stress were assessed. SCE means distribution appeared asymmetrical, identifying about 22 % of subjects characterized by a ‘high-respondent’ phenotype with more than 111 SCEs/cell. Confounding factors, such as smoking habit, wine and coffee consumption, work activity and hematological factors, showed a limited capacity to affect individual SCE responsiveness, however hemoglobin and uric acid seemed to antagonize DEB genotoxicity.