A family study of baseline chromosomal aberration and sister chromatid exchange frequencies
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文摘
Considerable variation exists in frequency of Sister Chromatid Exchange (SCE) and Cromosomal Aberration (CA) observed among individuals in different studies. Here, a possible source of variability, an inherent interindividual difference, which may be genetically influenced, has been studied by investigating familial patterns of SCE frequencies in 177 two-generation pedigrees, and CA frequencies in 50 two-generation pedigrees. The individuals belong to two different populations, one living in the city of Pisa, one living in two little towns near Pisa (Cascina-Navacchio). Some families are formed by parents and one, two or three children, others by mother and two children or by father and two children. The multifactor ANOVA revealed a significant effect of familiarity on the AC frequency (p = 0.02 excluding and p = 0.04 including gaps) and on the SCE frequency (p = 0.0001). The variance of CA and SCE frequencies between families is greater than variance within families, suggesting interfamily heterogeneity, and intrafamily homogeneity. In the Cascina-Navacchio population there is correlation between SCE frequencies in all relative combinations, while in the Pisa population there is correlation between father and mother and between sibs. The correlation of CA frequencies among sibs, between parents and between parent and offspring was not statistically different from zero, with the exception of the mother-son correlation in the Cascina-Navacchio population. Because of correlation between parents, which are not related, it seems right to exclude a genetic contribution to the SCE and CA frequencies.